This study was carried out to investigate the electron microscopic findings of the kidneys of rats after intraperitoneal injection of cadmium chloride. The Sprague-Dawley rats were intraperitoneally injected with cadmium chloride dissolved in
water,
once a day for three days.
These animals were sacrificed at 1, 3, 8, and 24 hr after the last injection. Control groups of the rats were also sacrificed in the same meaner. The kidney was extirpated and examined by transmission electron microscopy. The results obtained are
as
follows:
The podocytes show dilatation of endoplasmic reticulum and numerdous myelin-like residual bodies. The periglomerular fibrosis is also seen. The proximal tubular cells show fat droploetds, dilatation of endoplasmic reticulum, mitochondrial
swelling,
secondary lysosomes and occasional pyknotic nuclei. The basement membrane of the proximal tubule is ruptured and dnecrotic material is filled within in. The distal tubular fell is so changed as proximal tubular cell, but endoplasmic reticulum is
dilated
and lysosome are increased. The fat dropets in the proximal tubular cells are electron-dense after treatment with oxine, suggesting that the fat droplets may contain cadmium itself or related substances. Therefore, it can be concluded that the
cadmium
is directly acted to proximal tubular cells resulting in cellular injury and deposits the fat droplets in th4e cytoplasm of the proximal tubule. The cadmium is suggested to be deposited in the fat droplets.
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